信號轉導手冊

信號轉導手冊

图书基本信息
出版时间:2011-6
出版社:科學出版社
作者:布拉德肖
页数:384
书名:信號轉導手冊
封面图片
信號轉導手冊
内容概要
Ralph
A.Bradshaw編著的《信號轉導手冊(1細胞內外信號轉導機制原著第2版導讀版)(精)》包含350個章節,全面涵蓋細胞信號轉導領域。內容包括︰細胞內外信號轉導機制,蛋白質磷酸化和去磷酸化,鈣離子信號轉導、脂質介導的第二信使,蛋白質互作、環化核 酸,G蛋白、發育生物學中的信號轉導,轉錄與翻譯︰細胞核與細胞質事件.細胞內功能區隔信號轉導、胞間和細胞基質問的相互作用、疾病病理學。
《信號轉導手冊(1細胞內外信號轉導機制原著第2版導讀版)(精)》是生物學實驗室不可或缺的工具用書,適用于生物化學與分子生物學、細胞生物學等相關專業的高年級本科生、研究生.也可作為教師的教學和科研參考書,亦可供生物醫學、藥理學、免疫學及相關領域的研究人員參考。
书籍目录
英文目錄
撰稿人名單
第二版前言
第一版前言
導讀版第ヾ卷 細胞內外信號轉導機制
l.細胞信號轉導︰昨天、今天和明天
第一部分 起始︰胞外及質膜事件
A 分子識別
2.分子識別的結構和能量基礎
3.蛋白與蛋白相互作用的自由能概貌
4.分子社會學
5.抗原一抗體識別及其構象變化
6.抗原一抗體界面處的結合熱力學
7.免疫球蛋白-Fc受體相互作用
8.免疫球蛋白超折疊及其在分子識別中的多種用途
9.T細胞受體pMHc復合體
10.細胞表面黏附受體的機制特征
11.免疫突觸
12.NK受體
13.碳水化合物的識別與信號轉導
14.鼻病毒與其受體的相互作用
15.卜型人免疫缺陷病毒與其受體的相互作用
16.流感病毒神經氨酸黴的抑制劑
17.涉及血液縴維蛋白原及縴維蛋白的信號事件的結構基礎
18.整合素信號的結構基礎
19.G蛋白異源三聚體及其復合物的結構
20.G蛋白偶聯受體的結構
21.Toll樣受體的結構與信號
22.多種多樣的淋巴細胞受體
B 多通路受體
23.G蛋白偶聯受體的結構與功能︰從最近發現的晶體結構得到的啟示
24.趨化因子及其受體的結構與功能
25.G蛋白偶聯受體的結構及其被可擴散激素所激活的過程(參照β2型腎上腺素受體模型)
26.蛋白黴激活的受體
27.由激動劑導致的G蛋白偶聯受體的脫敏及細胞內吞化作用
28.由G蛋白偶聯受體形成的二聚化復合體的功能
29.細菌中的趨化性受體︰跨膜信號,敏感性,匹配及受體聚集
30.離子通道結構概論
31.STIM和Orai介導的鈣庫依賴性鈣信號及CRAC離子通道激活的分子機制
32.離子滲入性︰離子選擇性與進入阻斷的機制
33.煙堿乙 膽堿受體
34.與核 酸環化黴直接結合而被調節的離子通道
C 對受體的橫向比較研究
35.細胞因子受體概述
36.生長激素與泌乳激素家族及其受體︰受體激活和調節的結構基礎
37.以促紅細胞生成素受體為例的細胞因子信號
38.縴維原細胞生長因子(FGF)信號復合體
39.γ干擾素及其受體的結構
導讀版第2卷 蛋白質磷酸化和去磷酸化
導讀版第3卷 鈣離子信號轉導、脂質介導的第二信使
導讀版第4卷 蛋白質互作、環化核 酸
導讀版第5卷 G蛋白、發育生物學中的信號轉導
導讀版第6卷 轉錄與翻譯︰細胞核與細胞質事件
導讀版第7卷 細胞內功能區隔信號轉導、胞間和細胞基質間的相互作用、疾病病理學
索引
章节摘录
  Mechanistic Features of Cell-Surface Adhesion Receptors  Living cells constantly interact with their environment.Asa consequence,a number of sensory systems have evolvedfor the collection,processing,and integration ot a remark-able range of environmental stimuli arising from cell-celland cell-substrate interactions.For instance,developmentaland morphological processes in higher eukaryotes rely onthe orchestrated migration of cells in response to specificphysical and chemical cues;T cell activation relies on thelocalization and comDartmentalization of cell-adhesion andsignaling molecules;and adherent cells must respond to avariety of intracellular and extracellular mechanical forces.All of these processes rely on the engagement ot spemhc cell-surface receptors with the appropriate extracellularligand to report on the immediate physical environment bytransducing extracellular signals across the plasma mem-brane.This review examines the diversity of mechanismsthought to be involved in adhesion and signaling and high-1ights some of the shared principles that must be consideredfor all signaling pathways utilizing cell-surface receptors.  MECHANOSENSORY MECHAN ISMS  The ability to detect and respond to alterations in applied mechanical force is required for a number of cellular and developmental functions.This is particularly critical for adherent cells that directly contact the extracellular matrixfECM)and are subject to considerable physical deforma-tion.For example,sheer forces associated with blood flow are maior determinants of arterial tone and vascular reorgan-ization.At the cellular level,morphology and orientation are optimized to minimize mechanical stress and damage asso-ciated with variations in flow-related forces(see,for exam-ple,(1-31).Similarly,fibroblasts must be highly responsive Handbook of Cell Signaling,Three-Volume Set 2 ed-Copyright 0 2010 Elsevier Inc All rights reservedto the mechanical forces associated with alterations in theECM(reviewed in 141).  Considerable evidence points to focal adhesions,thesites of cell-substrate contact,as the sensors of mechanicalforce.Central to focal adhesion assembly and function arethe integrins.a family of α-βheterodimeric transmembraneglycoproteins that provide essential adhesive functions forcell migration and the establishment and maintenance of nor-mal tissue architecture.At least 18α and 8β chains allow forthe formation of multiple integrin heterodimers that are ableto display a spectrum of specificities for cell-surface adhesion molecules and for a range of ECM components,includingLaminin,collagen,and fibronectin.The integrin cytoplas-mic domains bind a variety of scaffolding and actin regula-tory proteins.which in tum recruit a large number of adaptor and signaling molecules.These physical links couple theintegrins to the downstream activation of numerous sxgnal-ing molecules,including MAP kinase,focal adhesion kinase,Src.and P13-kinase(see,for example,(4,51).Furthermore,integrin affinity is modulated by the activation state of the particular cell in question.
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评论与打分
  •     買回來才知道是英文版的。當時沒留意看,不過也很不錯。 要是英文字有點小,大點就好了,看起來會更舒服!